Influence of sleep disruption on protein accumulation in neurodegenerative diseases

Abnormal accumulation of disease proteins in the central nervous system is a neuropathological feature neurodegenerative disorders. Recently, growing body evidence has supported role disruption sleep-wake cycle development, pathological changes and abnormal protein diseases, especially Alzheimer’s Parkinson’s disease. Sleep deprivation promotes proteins. Interestingly, amyloid-? (A?) daily oscillations human cerebral spinal fluid (CSF) cleared more sleep. Both circadian genes hormones are associated with deposition. glymphatic pathway meningeal lymphatics have been shown to play critical A? clearance, which mediated by aquaporin (AQP-4) water channel on astrocytes. The rate clearance different during sleep/wake cycle. Most importantly, rhythms facilitate solutes CSF interstitial an AQP-4-dependent manner, further provides for involvement clearance.